In Situ Forming Formulation: Development, Evaluation, and Optimization Using 33 Factorial Design

Formulation Optimization and In-vitro Evaluation of Oral Floating Captopril Matrix Tablets using Factorial Design

Purpose: To develop a zero-order sustained release floating formulation of captopril, and optimize its drug release for enhanced oral bioavailability. Methods: A relatively new approach, 3 full factorial design, was used to formulate floating captopril matrix tablets and to systematically optimize its drug release using varying levels of xanthan gum and hydroxypropyl methylcellulose (HPMC) K100...

Formulation and Evaluation of Floating Nateglinide Tablets Using Factorial Design

Nateglinide is a novel, highly physiologic, glucose regulator recently approved for the treatment of type-2 diabetes mellitus. Nateglinide has a rapid onset and short duration of insulinotropic action that results in reduction of glucose level. The purpose of this study to develop a floating tablet of Nateglinide to enhance its bioavailability and sustained action. In the present study a 32 ful...

Development and evaluation of orally disintegrating tablets of Pramipexole using full factorial design

Pramipexole is the mostly prescribed drug in patients with Parkinson disease. The incidence of Parkinson disease is related to aging and mostly developed in elderly people with difficulty in swallowing or dysphagia. In the current study we aimed to develop an orally fast disintegrating tablet (ODT) of pramipexole as a preferable alternative in geriatric patients. Hence, the fast disintegration ...

formulation and optimization of pseudoephedrine and loratadine pellets using factorial design

Formulation, development, and optimization of immediate release nateglinide tablets by factorial design.

In the present study, selection of superdisintegrants among sodium starch glycolate, cross povidone, Starch-1500 and cross carmellose sodium (CCS) was carried out for development of immediate release nateglinide tablets (NTG). A 3(2) full factorial design was used to investigate the influence of two independent variables, i.e., amount of selected superdisintegrants and hardness of the tablets, ...